Star Trek, for all it's technology, was always a story about humans. Even Data's journey is about as human-centric as you can get. In that way even the recent series have mirrored an older age of science fiction ("Using science to opine on the human condition" etc).

The Culture novels managed to convince me that a story about true AI needs to not only look a little different, but fundamentally different. Not least, answering "Why still humans around?"