I don't think he was disparaging his looks, but rather his social skills. It's undeniable that Zuckerberg is not really an extroverted social butterfly with good public speaking skills, which is kind of a requirement if you want to get into politics.
During Bush's funeral I saw 4 respected, graceful presidents, and an orangutan. I won't comment on Trumps image or qualities as a president, however he clearly doesn't have hollywood looks, or even good looks.