We conclusively demonstrated that kinetic models of folding are critical to do better drug discovery against GPCRs and other target classes.

Or did you mean something more fundamental, like "the biophysics of protein folding is primarily determined by entropic-driven hydrophobic collapse, not enthalpic contributions from hydrogen bonding?"

>We conclusively demonstrated that kinetic models of folding are critical to do better drug discovery against GPCRs and other target classes.

How was this demonstration done? Or are you referring to building a better high throughput screening mechanism? I'm by no means a protein expert, but I am trying to learn more about them.

>Or did you mean something more fundamental, like "the biophysics of protein folding is primarily determined by entropic-driven hydrophobic collapse, not enthalpic contributions from hydrogen bonding?"

I don't want to minimize anything or anyones work. But conformation of experimental observations via molecular dynamics simulation isn't what I was thinking of - but maybe I am misunderstanding your claim. Its my own ignorance.