The Thinkpad build quality far eclipses the Asus'--to the point where handling them side by side (as we got to do since I have both of them) is a pretty eye-opening experience. The Thinkpad feels sturdy and the Asus feels flimsy. Also, whatever Asus is using for mouse drivers drove me insane. You'll see all kinds of online complaints about mouse lag and stutters. The Thinkpad does not have this issue, and also has 2-finger scrolling. You will not miss the difference in resolution compared to the huge upgrade in hardware quality.
I reverted to using Panasonic Toughbooks exclusively after buying, and subsequently returning a Lenovo W520 at $200 out of pocket, and I'm prepared to defend the following Toughbook rave in a verbal deathmatch if need be. Every other laptop I've encountered feels like cheap plastic. Apple, Lenovo, Toshiba, Asus, Dell, HP - literally every other laptop on the market today is poor in comparison. The hinges are weak, the design isn't sturdy, the little things aren't done right, and mostly they feel like uninspired works of crap designed to make a buck off of consumers.
The fact that Lenovo advertises some of their products as rugged is simply laughable.