This isn't about just ensuring that a conference is legitimate or not, it's a fundamental problem with presale events. You'll have the same issue if you have an ordinary merchant account as well, presales are a huge liability concern, especially for events, legitimate or no.
If you find yourself in circumstances where you require presale revenue in order to hold an event then I'd suggest using a crowdfunding platform like kicktarter or indiegogo or the specifically event oriented event tilt and picatic.
If you find yourself in circumstances where you require presale revenue in order to hold an event then I'd suggest using a crowdfunding platform like kicktarter or indiegogo or the specifically event oriented event tilt and picatic.