I've been doing that for the most of the last 5 years. It didn't happen immediately, but eventually the lack of social interactions and the general sterility of working alone became a nuissance. For me, it's easily fixed by just working from coffee shops from time to time - after a few trips to the coffee shops, with their distractions (music, conversations from nearby tables etc.), I quickly return to cherishing the sterility of my home office :)
Same for me. I've been in offices for around ~2 years of the last decade, but they don't usually agree with me. Good setups can exist for awhile, but ultimately privacy is easier.
Maybe I am misunderstanding, but a trip to a coffee shop doesn't sound social in any significant sense. When you work in an office you develop friendships with your coworkers and often socialise outside of the workplace. The conversation you overhear at a coffeeshop seems like a poor substitute.
Many people are already socially satisfied: When I work at home I carry on multiple conversations with people over IRC, IM, Skype, video chat, Google Hangouts, and occasionally even the venerable telephone. In real life I have a number of friends who share interests and outlooks, who I'm met in many interesting ways, and not just because we share an employer.
When I go to the cafe (I'm a different person from who you're replying to) I often go to meet up with other peers, but even when I don't, just being around other people mixes things up.
I share the sentiment - I have a social life outside of work so having it at work (with people I did not get to choose) is not crucial. When I go to coffeeshops I'm mostly looking to mix up my routine with the stimuli that coffee shop provides (noises, strangers at nearby tables) which I don't have at home. Something about the brain being bored with the constancy of the environment I suppose.